Job Description

Key Information
Salary: Dependent on relevant Postdoctoral experience. Future progression is based on annual performance review.
This role is eligible for ICR Sponsorship. Support will be provided for costs associated with Visa application. If you are considering relocating to the UK, further information can be found .
Job Details
Under the guidance of Dr George Poulogiannis, we are seeking to appoint a highly motivated and creative postdoctoral training fellow with a strong interest in cancer metabolism to carry out a systems-level research on understanding the metabolic determinants of endocrine therapy resistance for the identification of novel metabolic vulnerabilities. The successful candidate will play a key role in understanding the role of metabolic restructurings in the response to endocrine pathway therapies, using a systems-level approach and state-of-the-art metabolomics.
About you
The successful candidate must have:

• PhD in systems biology, biochemistry, cell biology, molecular biology or similar
• Proven ability to work independently and a strong desire to develop independent projects
• High level of competence in a wide range of laboratory techniques, protocol development and optimization and trouble-shooting
• Demonstrable extensive skills in in silico mathematical modelling including flux balance analysis, constraint-based modelling, and computational optimization techniques
• Demonstrable extensive skills in molecular/cell biology (cloning, gene editing, 2D/3D cell culture) and signalling (WB, IP, IF)

Candidates who are nearing completion of their PhD may apply, but confirmation on awarded PhD is required within 6 months of employment.
The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up to 7 years as PDTF at the ICR, providing total postdoctoral experience (including previous employment at this level elsewhere) does not exceed 7 years.
For general information on Postdocs at The ICR, more information can be found .
Signalling and Cancer Metabolism Group, Division of Cell and Molecular Biology
Work in the Signalling and Cancer Metabolism Group, led by Dr George Poulogiannis, in the Division of Cell and Molecular Biology focusses on understanding the signalling and metabolic networks that are related to cell growth and malignant transformation. In particular, we are interested in deciphering the genetic and molecular pathways that underlie metabolic addiction of cancer cells to known biosynthetic pathways and/or drive cancer cell adaptation to oxygen and nutrient deprivation. In line with these efforts, we aim to explore unique metabolic nodes for novel therapeutic intervention, biomarker selection and personalise treatment.
More information on the Signalling and Cancer Metabolism Group can be found .
What we offer

• A dynamic and supportive research environment
• Access to state-of-the-art facilities and professional development opportunities
• Collaboration with leading researchers in the field
• Competitive salary and pension

We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Dr George Poulogiannis via email on .
About The Institute of Cancer Research
Why work for us?
As a member of staff, you'll have exclusive access to a range of .
The ICR is committed to supporting overseas applicants applying for roles, here to find out further information.
The Institute of Cancer Research, London, is one of the world's most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. Further information about working at the ICR can be found .
At the Institute of Cancer Research, we champion diversity as we believe it fuels innovation and drives impactful research. We welcome applicants from all walks of life, valuing diverse perspectives that enrich our work.
Don't let a checklist of qualifications hold you back - if you're passionate about the role, we want to hear from you. Your unique experiences and backgrounds contribute to the richness of our team. We are committed to being an equal opportunity for all, regardless of ethnicity, gender, age, sexual orientation, disability, or any other dimension of diversity. Join us in creating an inclusive environment where everyone's voice is heard and valued.

Skills Required