Job Description

Analytical Associate Principal Scientist \xe2\x80\x93 Peptides/Oligonucleotides

AstraZeneca is a global, biopharmaceutical company where we not only focus on the discovery, development and delivery of life-saving medicines to patients but believe in sustainability and are determined to minimise the impact of our work on the environment. We are proud to be a great place to work and have a culture that inspires innovation and collaboration.

We empower our colleagues to express varied perspectives and at the same time feel valued, respected and rewarded for their ideas and creativity.

Pharmaceutical Technology and Development (PT&D) is the link between forward-thinking science and innovative medicines that help millions of people. We work across the entire value chain, designing and delivering active ingredients, formulations and devices required to support new medicines \xe2\x80\x93 from supplies for use in early toxicology studies and clinical trials to developing the technology to ensure drugs can be scaled up for commercial manufacture.

Within PT&D sits Chemical Development where we believe that nothing is impossible and are determined to push the boundaries of science to deliver medicines to patients. We combine technical knowledge and individual talent to design, develop and optimise synthetic routes and analytical methods that deliver active pharmaceutical ingredients in a sustainable and commercially viable way. We believe in innovation and continuous improvement, working closely with colleagues in academia and across industry, to ensure that we apply the newest technologies and principles in the development and delivery of our medicines.

We have an exciting opportunity in Chemical Development for an analytical associate principal scientist specialising in Tides to join our team. If you have experience in the development of synthetic peptides or oligonucleotides we would like to hear from you.

You will join a vibrant team working on the next generation of medicines, playing a key role in the analytical development of new medicinal products. As an experienced analytical scientist, you will be responsible for providing strategic and technical leadership towards the successful development of our Tides related active pharmaceutical ingredients. You will be working collaboratively with a multiskilled team including process chemists, engineers, project managers, quality assurance, supply chain and external partners to achieve the successful delivery of late phase development projects.

This is your opportunity to deliver medicines that have a direct impact on patients\xe2\x80\x99 lives!

Key accountabilities:

• Lead sophisticated Tides development projects for the analytical skill area from phase 2b/3 through to commercialisation
• Develop robust analytical control strategies for Tides APIs, leading to the registration of new medicines
• Deliver CMC content to regulatory filings throughout the clinical development and commercial filing phases
• Identify and solve project issues in collaboration with other departments
• Provide guide to drug projects and role model positive behaviours to advance new ways of working and scientific development
• Demonstrate scientific leadership to facilitate strategic development of drug projects and technical development of other scientists
• Mentor and develop junior colleagues, supporting them in reaching their full potential
• Contribute to the advancement of Chemical Development by defining and delivering continuous improvement plans

Essential skills and experience:

• BSc/PhD level education in a relevant subject area and a significant number of years\xe2\x80\x99 experience working within a Research & Development and Manufacturing environment, within the pharmaceutical industry
• A thorough understanding of key analytical techniques associated with Tides analysis; including NMR, chromatography, and mass spectrometry
• Experience in developing control strategies for Tides APIs
• Experience in supporting clinical and/or commercial manufacture and/or working with contract manufacturing organisations
• A thorough understanding of the principles and management of SHE and cGMP
• Experience of technical supervision, coaching and mentoring or leading small teams of people or scientific projects
• Experience in management of complex projects (including resources, risks, and partner management)

Desirable skills and experience:

• A good understanding of the overall drug development process from discovery through to launch
• Experience in delivering CMC content or contributions to regulatory filings for clinical and commercial products
• Excellent communication and strategic influencing skills across interfaces of subject area, culture, and expertise both internally and externally
• The ability to lead improvement projects confidently and successfully
• Ability to analyse and interpret complex situations and provide clear strategic direction

Please note applications must include your current CV and a covering letter which presents your key areas of strength and why you should be considered for the role.

Competitive Salary and Benefits

Close Date: 14th September 2023

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AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We align with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

Date Posted 22-Aug-2023

Closing Date 13-Sept-2023

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

AstraZeneca