Job Description

Job Category: Academic
:
Grade UE07: 41,064 - 48,822 per annum
CMVM / Deanery of Clinical Sciences / Centre for Cardiovascular Sciences
Full time: 35 hours per week
Fixed-Term: until 28/02/2027 (possibility of extension until 30/06/27)
The Opportunity:
We are seeking applications for a PDRA to join the dynamic research group of Dr Denby working on an exciting translational MRC funded study in which we are targeting scar-associated monocyte-derived macrophages (SAMac) to reduce fibrosis and the mechanisms associated with this. This project is in collaboration with the Ramachandran and Walmsley research labs of the Institute of Regeneration and Repair (IRR). This cutting-edge project involves sc/sn RNA sequencing and analysis of human and mouse kidney and liver samples, spatial transcriptomics, multiplex tissue staining, informative transgenic animal studies and metabolomics. The Denby lab is located in the Institute of Neuroscience and Cardiovascular Research (INCR) and is part of Edinburgh Kidney ( ). The studies to be undertaken will be conducted between INCR and the IRR.
This post is full-time (35 hours per week); however, we are open to considering part-time or flexible working patterns.
Your skills and attributes for success:

• The candidate must have a PhD (submitted or obtained) in immunology / biological sciences or related.
• Strong theoretical knowledge of the mechanisms driving fibrosis.
• Theoretical knowledge / experience of the application of flow cytometry and cell sorting.
• Experience in metabolomics and/or immunometabolism
• Experience in bioinformatic analysis of sc/sn RNA sequencing data
• Practical knowledge of cell culture and immunostaining.
• Knowledge of pre-clinical models of fibrosis.

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Informal enquiries are welcomed and can be addressed to Dr Laura Denby,
Please ensure you include the following documents in your application:

• CV
• Cover letter

As a valued member of our team you can expect:

• A competitive salary
• An exciting, positive, creative, challenging and rewarding place to work.
• To be part of a diverse and vibrant international community
• Comprehensive Staff Benefits, such as a generous holiday entitlement, competitive pension schemes, staff discounts, and family-friendly initiatives. Check out the full list on our

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Championing equality, diversity and inclusion
The University of Edinburgh holds a Silver Athena SWAN award in recognition of our commitment to advance gender equality in higher education. We are members of the Race Equality Charter and we are also Stonewall Scotland Diversity Champions, actively promoting LGBT equality.
Prior to any employment commencing with the University you will be required to evidence your right to work in the UK. Further information is available on our (opens new browser tab)
The University may be able to sponsor the employment of international workers in this role. This will depend on a number of factors specific to the successful applicant.
Key dates to note
The closing date for application is 14th August 2025.
Unless stated otherwise the closing time for applications is 11:59pm GMT. If you are applying outside the UK the closing time on our adverts automatically adjusts to your browsers local time zone.
About Us: As a world-leading research-intensive University, we are here to address tomorrow's greatest challenges. Between now and 2030 we will do that with a values-led approach to teaching, research and innovation, and through the strength of our relationships, both locally and globally.
About the Team:
The Deanery of Clinical Sciences (Head, Professor Lorna Marson) has an international reputation in clinical based research through the combination of basic, clinical and translational science and epidemiological studies, and as a part of the College of Medicine and Veterinary Medicine, offers unparalleled opportunities for ground-breaking interdisciplinary research in the bio-medical sciences.
The Deanery comprises 5 interdisciplinary Research Centres: the University of Edinburgh/BHF Centre for Cardiovascular Sciences (Director, Professor Andy Baker), the Centre for Clinical Brain Sciences (Director, Professor Colin Smith), the Centre for Inflammation Research (Director, Professor David Dockrell), the Centre for Regenerative Medicine (Director, Professor Stuart Forbes), the MRC Centre for Reproductive Health (Director, Professor Andrew Horne) - of which the latter three Centres comprise the Institute for Repair and Regeneration; as well as the Edinburgh Imaging Facility (Director, Professor Dave Newby) the Edinburgh Clinical Research Facility (Director, Professor Neeraj Dhaun) and the Edinburgh Dental Institute.
Clinical Sciences employs around 1000 members of academic and support staff and has over 550 Honorary members who contribute significantly to teaching and research. The Deanery is a major contributor to the undergraduate MBChB curriculum and has approximately 1000 registered post graduate students studying a range of PhD, MD, taught and research MSc and on-line distance learning programmes. The Deanery can be found at the Bioquarter Campus (Queen's Medical Research Institute, Chancellor's Building, Royal Infirmary of Edinburgh the Scottish Centre for Regenerative Medicine and the Royal Hospital for Children and Young People), the Lauriston Building, Lauriston Place, the Western General Hospital and the Royal Edinburgh Hospital.