Job Description

Job number

MED05508

Faculties

Faculty of Medicine

Departments

Department of Surgery & Cancer

Salary or Salary range

49,017 - 57,472 per annum

Location/campus

Hammersmith Campus - On site only

Contract type work pattern

Full time - Fixed term

Posting End Date

16 Nov 2025

About the role

------------------


The post will utilise high content, single-cell resolved microscopy to investigate PARP trapping in ovarian high grade serous carcinoma. Previous work from the McNeish has described a novel PARP1 biosensor capable of providing live, single-cell resolved readouts of PARP1 trapping by PARP inhibitors at sites of drug-induced DNA damage. This was achieved through double CRISPR knock-in of eGFP and mCherry and the 5' and 3' ends of the PARP1 locus in OVCAR4 cells.



The post-holder will be expected to develop the technology with a view to generating a lentivirus construct that will allow the biosensor to be expressed in multiple cells via viral transduction rather than CRISPR knock-in. The post-holder will generate the constructs and evaluate their efficiency in human high grade serous carcinoma cells.



In addition, the post-holder will evaluate label-free markers for evaluating cell cycle state in high grade serous carcinoma cells.



The postholder will be expected to undertake project management and/or supervision multi-disciplinary teams. In addition, they will be expected to submit publications to refereed journals and to attract external research funding.

What you would be doing

---------------------------


To take initiatives in the planning of research To direct the work of small research teams To identify and develop suitable techniques, and apparatus, for the collection and analysis of data To conduct data analysis To ensure the validity and reliability of data at all times To maintain accurate and complete records of all findings To write reports for submission to research sponsors To present findings to colleagues and at conferences To submit publications to refereed journals To provide guidance to staff and students

What we are looking for

---------------------------


You will have a PhDin cancer biology and microscopy physics and experience in a broad range of techniques including molecular cloning and performing and analysing single cell-resolved high content microscopy using FLIM-FRE, gene editing using CRISPR/Cas9 methodology.

What we can offer you

-------------------------


You'll be part of a multidisciplinary team at the forefront of ovarian cancer research, working in a collaborative and supportive environment. Imperial College London offers world-class facilities, career development opportunities, and a vibrant research culture.

Further information

-----------------------


This is a fulltime, fixed term for 6 months role based at Hammersmith Campus.



Please submit an application via Imperial College's job portal link. Informal enquiries are welcome and can be directed to Sophie Lyons (s.lyons@imperial.ac.uk).

Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range

43,863 - 47,223 per annum.

Available documents

-----------------------


Attached documents are available under links. Clicking a document link will initialize its download.

Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities mentioned above.

We reserve the right to close the advert prior to the closing date stated should we receive a high volume of applications. It is therefore advisable that you submit your application as early as possible to avoid disappointment.



If you encounter any technical issues while applying online, please don't hesitate to email us at support.jobs@imperial.ac.uk. We're here to help.

About Imperial

Welcome to Imperial, a global top ten university where scientific imagination leads to world-changing impact.



Join us and be part of something bigger. From global health to climate change, AI to business leadership, here at Imperial we navigate some of the world's toughest challenges. Whatever your role, your contribution will have a lasting impact.



As a member of our vibrant community of 22,000 students and 8,000 staff, you'll collaborate with passionate minds across nine London campuses and a global network.



This is your chance to help shape the future. We hope you'll join us at Imperial College London.

Our Culture

We work towards equality of opportunity, to eliminating discrimination, and to creating an inclusive working environment for all. We encourage applications from all backgrounds, communities and industries, and are committed to employing a team that has diverse skills, experiences and abilities. You can read more about our commitment on our webpages.



Our values are at the root of everything we do and everyone in our community is expected to demonstrate respect, collaboration, excellence, integrity, and innovation.