Job Description

Research Associate

OrthoBio Therapeutics focuses on the use of cutting-edge RNA-based therapeutics to treat musculoskeletal disease in humans and animals. The company's R&D hub is situated in incubator space on the Biomedical Campus at the University of Cambridge. Our central location within Europe's largest biomedical campus affords us access to state-of-the-art core facilities and a unique opportunity to work closely with academic partners to further our mission. It also creates an unrivalled opportunity for professional scientific growth and networking. Our Scientific Advisory Board includes Bob Langer (MIT, co-founder Moderna), Matt Porteus (Professor of Paediatrics at Stanford, co-founder of 3 CRISPR companies), Russ Warren (Emeritus Surgeon-in-Chief, Hospital for Special Surgery), Brian Cole (Chair of Orthopaedic Surgery, Rush University), Ralph Snyderman (Chancellor Emeritus, Duke University) and Al Russell (Head of Preclinical Genome Editing, CRUK CI, University of Cambridge)

About the position

We're looking for a Research Associate to support our preclinical research program, helping evaluate novel RNA therapeutic solutions for musculoskeletal disease.

This is a full-time position with a competitive salary and benefits package that is funded for 24 months in the first instance. Candidates may on occasion be asked to work outside of normal working hours.

Who you are

You work well in a fast-paced and extremely focused startup environment where creativity and self-reliance are encouraged. You are a natural communicator and enjoy being part of a team. You can multi-task without losing focus and deliver results under tight deadlines. You are committed to helping us translate this technology into the clinic to benefit our patients.
Primary responsibilities

Maintaining mammalian cell lines and using them to screen novel therapeutics. Manufacturing and testing novel non-viral delivery vehicles. Performing mammalian tissue dissections. Extracting nucleic acids and proteins from cells and tissue. Ensuring timely submission of test samples to relevant core facilities within the institute (e.g. genomics). Preparing next-generation sequencing libraries for deep sequencing. Performing molecular techniques including PCR, RT-qPCR, ELISA and cloning. Analysing genome editing outcomes and functional readouts. Providing cross-disciplinary support for our drug development pipeline.
Essential Experience, Knowledge and Skills

Master's degree in Biology, Biochemistry or a similar discipline. At least two years of full-time wet-lab experience with aseptic cell culture techniques including maintaining mammalian cell lines. Experience with PCR Experience with gDNA, RNA and protein extraction Ability to work independently and as part of a hard-working, motivated, and enthusiastic team. Proactive and flexible, with proven ability to perform on tight timelines. Effective in oral and written communication with excellent organisational and record keeping skills.
Job Type: Full-time

Pay: 35,000.00-40,000.00 per year

Work Location: In person