Working within under the supervision of Professor Neil Dixon, the post is funded by the BBSRC strategic Longer and Larger grant "Rules of life in CO2-driven microbial communities: Microbiome engineering for a Net Zero future". In this project we will deploy state of the art metagenomic engineering tools to permit in situ genetic augmentation to modify microbiome function. The long-term global is that these engineered microbiomes will support the transition to a sustainable bioeconomy and carbon-negative production of chemicals.
You will be responsible for conducting research under the supervision of Profs Dixon and Nixon to engineer the microbial communities from hot springs that successfully grow on CO2 and H2. You will be responsible for the design and deployment of CRISPR-based microbiome engineering tools, to both isolate individual community members for analysis and to augment the entire microbiome community with modified functions. These isolates and augmented communities will phenotyped and further adapted under batch cultivation experiments and continuous cultivation studies using flow through bioreactors. You will work closely with other postdocs and PhD students in this project, who will be applying complimentary approaches to the same systems (including metabarcoding, metagenomic and metatranscriptomic sequencing approaches, as well as multi-species metabolic modelling). You will also be supported by senior technical specialists.
What you will get in return:
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