Job Description

Job number

MED05209

Faculties

Faculty of Medicine

Departments

National Heart & Lung Institute

Salary or Salary range

43,003 - 56,345 per annum

Location/campus

Royal Brompton Campus - On site only

Contract type work pattern

Full time - Fixed term

Posting End Date

27 May 2025

About the role

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This post is an excellent opportunity for a post-doctoral scientist with an interest in respiratory disease to join the Margaret Turner Warwick Centre for Fibrosing Lung Disease at the National Heart and Lung Institute.



The post holder will be a highly motivated individual interested in investigating the molecular pathways which promote development of idiopathic pulmonary fibrosis. The overall aim of the MTW Centre's research programme is to develop more effective anti-fibrotic drugs and a personalised medicine approach for treatment of patients who develop this fatal chronic progressive lung disease.

What you would be doing

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A range of in vitro and ex vivo models will be utilised in the project including 2D- and 3D-cultures of patient-derived primary lung epithelial cells and fibroblasts and precision cut lung slices. Studies might also include scRNAseq and spatial transcriptomic analysis in non-IPF and IPF tissue samples. These studies will improve our understanding of disease mechanisms in IPF, with the aim of identifying new targets for therapeutic intervention.

What we are looking for

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a PhD in Biological Sciences or a closely related discipline or be awaiting viva voce examination

Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range 43,003 - 46,297 per annum

Practical experience in human primary 2D- or 3D-cell culture and creation of human precision cut tissue slices Practical expertise in a range of functional cell biology assays (eg cell migration, proliferation) and molecular biology techniques (eg RT-PCR, cloning, siRNA, CRISPR) Practical experience in protein analysis techniques (eg ELISA, western blotting, IF staining) Experience in scRNAseq/spatial transcriptomics and bioinformatic analysis will be an advantage

What we can offer you

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The opportunity to continue your career at a world-leading institution and be part of our mission to use science for humanity. Benefit from a sector-leading salary and remuneration package (including 39 days' annual leave and generous pension schemes). Access to a range of workplace benefits including a flexible working policy from day one, generous family leave packages, on-site leisure facilities and cycle-to-work scheme. Interest-free season ticket loan schemes for travel. Be part of a diverse, inclusive and collaborative work culture with various staff networks and resources to support your personal and professional wellbeing.

Further information

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This is a full-time post and a fixed-term until the 31/05/2026 based at the Royal Brompton Campus.



If you require any further details about the role, please contact: Dr Alison John- a.john@imperial.ac.uk.

Available documents

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Attached documents are available under links. Clicking a document link will initialize its download.

Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities mentioned above.

We reserve the right to close the advert prior to the closing date stated should we receive a high volume of applications. It is therefore advisable that you submit your application as early as possible to avoid disappointment.



If you encounter any technical issues while applying online, please don't hesitate to email us at support.jobs@imperial.ac.uk. We're here to help.


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About Imperial

Welcome to Imperial, a global top ten university where scientific imagination leads to world-changing impact.



Join us and be part of something bigger. From global health to climate change, AI to business leadership, here at Imperial we navigate some of the world's toughest challenges. Whatever your role, your contribution will have a lasting impact.



As a member of our vibrant community of 22,000 students and 8,000 staff, you'll collaborate with passionate minds across nine London campuses and a global network.



This is your chance to help shape the future. We hope you'll join us at Imperial College London.


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Our Culture

We work towards equality of opportunity, to eliminating discrimination, and to creating an inclusive working environment for all. We encourage applications from all backgrounds, communities and industries, and are committed to employing a team that has diverse skills, experiences and abilities. You can read more about our commitment on our webpages.



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