Job Description

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UE07: \xc2\xa337,099 - \xc2\xa344,263 Per Annum, Pro Rata.

CMVM / School of Molecular and Clinical Medicine / MRC Human Genetics Unit / MRC Institute of Genetics and Cancer.

Fixed Term Contract - 3 Years; Full Time - 35 Hours Per Week.

We are looking for an enthusiastic and motivated chromatin biologist to join Nick Gilbert\'s research group ( ; @chromatinlab). Our group forms part of a vibrant research community within the MRC Human Genetics Unit where our specific focus is understanding how chromatin structure regulates gene expression and genome stability. Strong interest in chromatin biology and/or gene regulation is crucial whilst previous experience in molecular biology, genome-engineering, FISH, super-resolution microscopy and 3C/Hi-C techniques are desirable.

The Opportunity:

This project aims to investigate how RNA-mediated large-scale chromatin structure affects transcription and will focus on a role for phase-separated protein/RNA structures. This is a unique opportunity for a PhD student or an experienced post-doctoral researcher to join a diverse team of chromatin biologists, physicists and bioinformaticians all investigating chromatin architecture and regulation.

Your skills and attributes for success:

• PhD in a relevant subject.
• Strong interest in chromatin biology.
• Previous experience in FISH and/or super resolution microscopy.
• Molecular biology and tissue culture techniques including CRISPR, ChIP, RNAi, next generation sequencing.
• Ability to work independently and as a member of a collaborative team.

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As a valued member of our team you can expect:

An exciting, positive, creative, challenging and rewarding place to work. We give you support, nurture your talent and reward success. You will benefit from a competitive reward package and a wide range of staff benefits, which includes a generous holiday entitlement, a defined benefits , staff discounts, , flexible working and much more. Access our for further information and use our to find out the total value of pay and benefits provided.

The University of Edinburgh holds a Silver Athena SWAN award in recognition of our commitment to advance gender equality in higher education. We are members of the Race Equality Charter and we are also Stonewall Scotland Diversity Champions, actively promoting LGBT equality.

If invited for interview you will be required to evidence your right to work in the UK. Further information is available on our webpage.

The University is able to sponsor the employment of international workers in this role. If successful, an international applicant requiring sponsorship to work in the UK will need to satisfy the UK Home Office\'s English Language requirements and apply for and secure a Skilled Worker Visa.

About Us: As a world-leading research-intensive University, we are here to address tomorrow\'s greatest challenges. Between now and 2030 we will do that with a values-led approach to teaching, research and innovation, and through the strength of our relationships, both locally and globally.

About the Team:

A deep understanding of human genome function - particularly for the non-coding genome - is an outstanding grand challenge. Our mission is to discover how our genome controls the function of molecules, cells and tissues, in health and disease, connecting human genetic variation to phenotype.

Multidisciplinary HGU research programs embrace genetic, computational, biochemical, cellular, model organism and clinical approaches, to gain meaningful insights across scales and dynamic processes, with cross-cutting themes in 4D Cellular Medicine and Genome Interpretation.

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The MRC Human Genetics Unit is part of the Institute of Genetics and Cancer (IGC). This partnership with CRUK Edinburgh Centre and Centre for Genomic and Experimental Medicine Centre aims to understand development and disease by using the latest developments in genetic, genomic, cellular and clinical science. The partnership provides access to state of the art scientific facilities, scientific infrastructure and business support, including on site Advanced Imaging Resource, Animal Model support, Bioinformatics Analysis Core, DNA sequencing, Flow Cytometry, Mass Spectrometry, HTPU microarray. The IGC also offers a highly collegial environment with excellent local career development support, active social, wellbeing and sustainability related groups making it a very desirable and supportive working environment.

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University of Edinburgh