Job Description

Ref Number

B02-08845

Professional Expertise

Research and Research Support

Department

School of Life & Medical Sciences (B02)

Location

London

Working Pattern

Full time

Salary

43,374 51,860

Contract Type

Fixed-term

Working Type

On site

Available for Secondment

No

Closing Date

03-Jul-2025

About us

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UCL is one of the top Universities in the world with superb facilities for biomedical sciences and its translation to human disease. The successful candidate will focus on translational research in autoimmune rheumatic disease spanning disease pathomechanisms toward translational medicine to early phase clinical trials. Thus, contributing to the development of precision medicine and novel therapies. The work will build on existing excellent links with UCLH and complete a project that commenced early in 2025. The work will involving patient recruitment, processing of samples from patients with autoimmune disease and carried out at the Centre for Rheumatology in the Rayne Building, which has outstanding flow-cytometry infrastructure and technical support.

About the role

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This six-month research position starting September 2025 focuses on systemic lupus erythematosus (SLE) immunology research. The role investigates B cell and T cell dysfunction in SLE patients to identify biomarkers predicting response to B cell targeted therapies. The researcher will independently conduct hands-on laboratory work using advanced molecular and cellular techniques, including multiparameter spectral flow cytometry, ELISA, and cytometric bead arrays. Key responsibilities include processing patient samples, performing whole blood depletion assays, and analysing T cell activation patterns to evaluate novel B cell targeting agents. Beyond laboratory work, the position requires meticulous documentation, sample management, and maintaining regulatory compliance. The researcher will contribute to manuscript preparation, grant writing, and present findings to colleagues. Laboratory management duties include inventory control and safety protocol adherence. This translational research directly impacts clinical treatment outcomes for SLE patients. The role offers professional development opportunities through industry and academic collaborations, making it ideal for immunology researchers seeking meaningful clinical research experience. This post is available for 6 months.

About you

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The successful candidate requires a PhD in Immunology with expertise in multiparameter flow cytometry and cellular immunology. Essential experience includes clinical specimen processing, serum and PBMC isolation, cryopreservation, and performing whole blood depletion assays, independently. Strong B and T cell biology knowledge, statistics, and research publication record with experience of performing whole blood assays are required. Technical skills needed: sterile cell culture, advanced flow cytometry analysis, and basic computational statistics. Excellent written and verbal communication abilities are essential for presenting complex data to diverse audiences. Personal attributes include research excellence commitment, collaborative teamwork with multidisciplinary teams, exceptional attention to detail for data management, and adherence to regulatory requirements. Computational bioinformatics experience is desirable but not essential.

What we offer

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This is an exciting opportunity to join a multidisciplinary team working across the Division of Medicine. As well as the exciting opportunities this role presents, we also offer some great benefits some of which are below: o 41 Days holiday (27 days annual leave 8 bank holiday and 6 closure days) o Additional 5 days' annual leave purchase scheme o Defined benefit career average revalued earnings pension scheme (CARE) o Cycle to work scheme and season ticket loan o Immigration loan o Relocation scheme for certain posts o On-Site nursery o On-site gym o Enhanced maternity, paternity and adoption pay o Employee assistance programme: Staff Support Service o Discounted medical insurance Visit https://www.ucl.ac.uk/work-at-ucl/reward-and-benefits to find out more.

Our commitment to Equality, Diversity and Inclusion

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As London's Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world's talent. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong. We therefore particularly encourage applications from candidates who are likely to be underrepresented in UCL's workforce. These include people from Black, Asian and ethnic minority backgrounds; disabled people; LGBTQI+ people Our department holds an Athena SWAN Silver award, in recognition of our commitment and demonstrable impact in advancing gender equality.