Job Description

About us This research will be conducted in the Molecular Biology Development and Disease (MBDD) laboratory, within the Department of Preclinical and Fundamental Science at the UCL Institute of Cardiovascular Science (ICS). As part of the Faculty of Population Health Sciences and the wider School of Life and Medical Sciences (SLMS), the ICS fosters interdisciplinary research spanning discovery-based laboratory science, clinical, translation and experimental medicine as well as healthcare evaluation, implementation and policy.About the role A full-time Research Fellow is sought for a British Heart Foundation-funded project investigating a novel regulator of vascular function and its role in hypertension. This project builds upon prior findings from the Molecular Biology Development and Disease (MBDD) laboratory, demonstrating that constitutive POU4F2/Brn-3b in knockout (KO) mutants develop vascular abnormalities and contractile dysfunction arising from the dysregulation of genes involved in calcium signalling and stress responses, patterns frequently observed in human cardiovascular diseases (CVD).About you . PhD in Biomedical Sciences or other relevant subject
. A strong understanding of the principles of gene expression, specifically transcriptional regulation.
. Knowledge of transgenic models and experience with performing in-vivo procedures using such models
. Prior laboratory experience should include basic molecular and cellular biology and related research techniques e.g. - gene editing and manipulation, PCR genotyping. - quantitative analysis e.g. qRT-PCR, western blotting. - localization studies and imaging: e.g. immunohistochemistry and immunofluorescent staining and analysis, confocal microscopy.What we offer As well as the exciting opportunities this role presents, we also offer some great benefits some of which are below: xe2x80xa2 41 Days holiday (including 27 days annual leave 8 bank holiday and 6 closure days) xe2x80xa2 Defined benefit career average revalued earnings pension scheme (CARE) xe2x80xa2 Cycle to work scheme and season ticket loan xe2x80xa2 On-Site nursery xe2x80xa2 On-site gym xe2x80xa2 Enhanced maternity, paternity and adoption pay xe2x80xa2 Employee assistance programme: Staff Support Service xe2x80xa2 Discounted medical insurance The full range of staff benefits can be found here: https://www.ucl.ac.uk/human-resources/pay-benefits/staff-benefitsOur commitment to Equality, Diversity and Inclusion As Londonxe2x80x99s Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the worldxe2x80x99s talent. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong. We therefore particularly encourage applications from candidates who are likely to be underrepresented in UCLxe2x80x99s workforce. These include people from Black, Asian and ethnic minority backgrounds; disabled people; LGBTQI+ people; and for our Grade 9 and 10 roles, women.
You can read more about our commitment to Equality, Diversity and Inclusion here: https://www.ucl.ac.uk/equality-diversity-inclusion/Available documents

University College London