Job Description

200 staff. Limitless Potential. One team - Cancer Research Horizons.Scientist xe2x80x93 High Throughput Screening (Antibody Discovery)xe2x80x93 Under the leadership ofSalary: xc2xa333,000 - 38,150 per annum depending on experience(dependent on experience) plus (includes up to 12% pension contribution and income protection)Reports to: Principal Scientist, Antibody DiscoveryDepartment: Research and InnovationContract: PermanentHours: Full time 35 hours per week (flexible working requests considered)Location: Cori Building, Granta Park, CambridgeClosing date: 26th May 2025 23:55. This vacancy may close earlier if a high volume of applications is received or once a suitable candidate is found, therefore we strongly recommend that you apply early to avoid disappointment. If you require more time to apply as part of a reasonable adjustment, please contact as soon as possible.Visa Sponsorship: Cancer Research UK is able to consider visa sponsorship for this vacancy (conditions apply at this level). If this applies to you, please ensure that this is clearly marked on your application.Interview schedule: Initial screening interviews may be conducted via MS Teams, week commencing 2nd June 2025 and in person interviews to be held at Granta Park, 11th-12th June 2025.At Cancer Research UK, we exist to beat cancer.We currently have an exciting opportunity within our Drug Discovery team for an experienced Scientist to expand and enhance our capabilities in therapeutic antibody discovery.About CRUK Drug DiscoveryAs the worldxe2x80x99s biggest medical research charity, wexe2x80x99ve helped bring eleven new cancer drugs to market. However, there is still an urgent need to bring more effective treatments to patients faster.We have recently developed a new approach to driving therapeutic innovation through the creation of Cancer Research Horizons (CRH). We have brought together Cancer Research UKxe2x80x99s established drug discovery teams under one organisation and leadership team, combining our unique pipeline of cancer biology expertise and access to CRUKxe2x80x99s world-class academic network, cutting edge technology platforms and clinical expertise to 1) bring new treatments to patients faster and 2) tackle the biggest challenges in discovering cancer drugs by seeking out more radical ideas and embracing risk in our bid to achieve success.Based at sites in Cambridge, the CRUK Scotland Institute in Glasgow, the Francis Crick Institute in London, and Newcastle University, Cancer Research Horizons employs ~200 staff from both industrial and academic backgroundsIn this lab-based role you will use your knowledge and experience with biochemical and cell based high throughput screening technology to develop and execute high throughput screening assays, and associated drug discovery activities within the Antibody Discovery team (c11 people) of Cancer Research Horizons. Youxe2x80x99ll bring with you experience of developing and running cell-based assays to identify early-stage drug candidates xe2x80x93 ideally antibodies, but experience of small molecules will be considered.In return you will have the opportunity to work in an inclusive environment where we welcome creative thinking and new ideas, we would welcome your input on implementation of new technologies and improvements to existing processes and infrastructure. Furthermore, we actively encourage our colleagues to celebrate our science, by attending conferences, presenting posters, giving talks at events and publishing papers.What will I be doing?Working on the development and execution of high throughput screening assays to enable the identification and characterisation of therapeutic antibodies.Contributing to project progression as part of a multi-disciplinary team.Utilising biochemical and cell-based assays to characterise functional properties of therapeutic antibodies (e.g. IC50 or EC50 determination).Working with a variety of assay formats, detection technologies and laboratory automation to maximise efficiency.Maintaining relevant technical and intellectual expertise relevant to the field (e.g. assays development and antibody discovery).Recording, tracking and presenting data for project team meetings.What skills will I need?PhD in relevant field or Degree with equivalent drug discovery experience.Strong knowledge of biochemical and cell-based high throughput screening (HTS) technologies utilized in pre-clinical antibody drug discovery.Experience of developing and running high throughput cell-based assays to identify early-stage drug candidates xe2x80x93 ideally antibodies, but experience of small molecules will be considered.Extensive experience of working with a variety of assay formats and detection technologies such as flow cytometry, high content imaging, ELISA, MSD and HTRF assays.Experience of applying a range of laboratory automation solutions (e.g. Viaflo, Hamilton, HighRes) to support drug discovery cascades is highly desirable.Proactive, with a xe2x80x98can doxe2x80x99 attitude; with a demonstrated ability to prioritise own work effectively, multi-task and adapt flexibly to changing priorities.Strength in collaborative working and proven ability to interact and effectively communicate scientific objectives and project results with colleagues.Demonstrated interest in scientific innovation and driving new capability development to support antibody discoveryWhat will I GainOur organisation values are designed to guide all that we do.Bold: Act with ambition, courage and determinationCredible: Act with rigour and professionalismHuman: Act to have a positive impact on peopleTogether: Act inclusively and collaborativelyWexe2x80x99re looking for people who can believe in and embody these organisation values and can use them to drive forward progress against our mission to beat cancer.If youxe2x80x99re interested in applying and excited about working with us but are unsure if you have the right skills and experience wexe2x80x99d still love to hear from you.What will I gain?We create a working environment that supports your wellbeing and provide a generous benefits package, a wide range of career and personal development opportunities and high-quality tools. Our policies and processes enable you to improve your work-life balance, take positive steps in your career and achieve your personal wellbeing goals.You can explore our benefits by visiting our .How do I apply?We operate an anonymised shortlisting process in our commitment to equality, diversity and inclusion. CVs are required for all applications; but we wonxe2x80x99t be able to view them until we invite you for an interview. Instead, we ask you to complete the work history section of the online application form for us to be able to assess you fairly and objectively.For more information on this career opportunity please or contact us at .For more updates on our work and careers, follow us on: , , , and .Our vision is to create a charity where everyone feels like they belong, benefits from and participates in, the work we do. We actively encourage applications from people of all backgrounds and cultures, in particular those from ethnic minority backgrounds who are currently under-represented.We want to see every candidate performing at their best throughout the job application process, interview process and whilst at work. We therefore ask you to inform us of any concerns you have or any adjustments you might need to enable this to happen. Please contact or 020 3469 8400 as soon as possible.Unfortunately, we are unable to recruit anyone below the age of 18, so that we can protect young people from health & safety and safeguarding risks.

Cancer Research UK