Job Description

For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we'll help you build a career that you can feel passionate about.
The Role
Can you independently run a range of immunological assays and develop new assays to support our invitro capabilities?
Have you got immunological experience in Immuno-oncology, autoimmune disease and inflammation (inc. neuroinflammation), infection or microbiome programs?
Are you our next immunologist?
Our waterside site down in Portishead, Bristol has an opportunity for an additional Senior Scientist to join their in vitro biology team in a permanent role!
You'll be working independently under strategic guidance with understanding and application of scientific and technical standards, principles, theories, concepts, and techniques in a predominantly lab-based environment.
What You'll be Doing

• Independently run a wide range of immunological assays using techniques such as flow cytometry, IncuCyte, MACS sorting, culture and differentiation of primary cells and cell lines, ELISA, Luminex, TR-FRET, and ex-vivo tissue processing.
• Implement available assays and develop new immunological assays to support the in vitro biology capabilities in the areas of immuno-oncology, autoimmune disease and inflammation (inc. neuroinflammation), infection or microbiome programs.
• Interrogate own and others data to generate reports where conclusions/future directions are scientifically sound and provide technical and scientific leadership to drive project progression.
• Guide, coach and mentor junior scientific staff, helping to train on specific techniques and provide technical knowledge, where needed.
• Project lead or deputy-Project lead or execute IVB studies with minimal supervision from the Project lead.
• Leverage BD/CS and operational team to introduce novel work for the site, including scoping calls with client and revision of scientific project proposals.

Skills and Experience

• MSc in Immunology with Industry experience or PhD in Immunology desirable.
• Expertise in B and T cell immunology.
• Demonstrable lab-based experience in disciplines of immuno-oncology, autoimmune disease and inflammation (inc. neuroinflammation).
• Awareness of Health and Safety standards within the labs and ability to work safely within this environment.
• Excellent communication skills, able to relay scientific information accurately.
• Strong passion for working within drug discovery, able to keep abreast of industry updates and share amongst peer groups.
• Strong problem solving and communication skills, with ability to work collaboratively within a team.
• Proficient in IT - Microsoft, Outlook, and Teams.
• Clear understanding and grasp of the drug discovery process.

Nice to have:

• Previous industry experience in the labs, ideally from pharma /CRO / biotech.
• Some demonstrable project leadership skills, with ability to liaise effectively with internal and external stakeholders.
• Experience of working in a multidisciplinary unit on integrated drug discovery projects.
• Demonstrable practical skills in executing biological assays in a pharma/biotech/CRO environment.

What We offer You:
A very comprehensive benefits package from day one, including a generous pension contribution, and flexible health benefits.
Access to great discounts via our CREDS discount scheme.
Global opportunities and strong career progression.
The chance to work on several varied projects and liaise globally and nationally with other business areas.
To be able make a difference to health and wellbeing of people.
To continue your own career growth.
Parental leave.
Group Life Assurance and Group Income Protection.
Remote GP access 24/7.
Well being support and initiatives.
Cycle to work scheme.
About Discovery
Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 350 patents and 80 preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.
About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients' clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.
With over 20,000 employees within 110 facilities in over 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client's unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world.
At Charles River, we are passionate about our role in improving the quality of people's lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly worked on 80% of the drugs approved by the U.S. Food and Drug Administration (FDA) in the past five years.
At Charles River Laboratories, we recognize and recruit all talent. We are a company committed to the principle of diversity and inclusion and work daily in this direction.

Skills Required