Job Description

We are seeking a motivated, creative, and meticulous bench scientist with a track record or interest in developing Complex In Vitro Models. These can include organoid technology, applied bio-engineering, and/or microphysiological systems for drug development.

The candidate would join the Complex In Vitro Models (CIVM) team within In Vitro In Vivo translation (IVIVT) department in GSK\xe2\x80\x99s research organization at the Stevenage site in the United Kingdom. CIVM\xe2\x80\x99s mission is to improve predictive and translational value of preclinical models. We strive to improve models to understand mechanism of action, efficacy, safety and metabolism, aiming to assess these in the same systems whenever possible, and ultimately to use these systems to refine, reduce, and replace animal models. The CIVM group engages in dynamic, matrixed collaborative projects across therapeutic areas and other IVIVT platform groups.

The successful candidate will be responsible for developing, qualifying, and validating immune-competent, translational Complex in Vitro Models.

We would be happy to consider candidates at a grade 8 or 7 level.

We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme.

We embrace modern work practises; our Performance with Choice programme offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work.

Discover more about our company wide benefits and life at GSK on our webpage

In this role you will

• Develop and apply complex in vitro assays including 3D patient derived organoids (PDO), PDX derived organoids (PDXOs), microphysiological systems, and organ-on-a-chip approaches for epithelial barrier, inflammatory disease, oncology, and/or dermal models.
• Develop and apply advanced cellular models incorporating components of the immune system and early profiling of drug candidates across different disease areas.
• Perform cell-based assays in combination with advanced imaging technologies on organoids and microphysiological systems to support projects and different drug modalities.
• Test the functional consequences of genetic variants in CIVM cell-based model systems using methods that include CRISPR-based gene editing technologies.
• Collaborate in a matrix team and cross-functional environment to ensure optimal delivery of project and department objectives to the highest possible scientific standard.
• Write protocols, design and execute laboratory experiments, apply advanced data analysis, interpret data, compile reports, and communicate findings with an emphasis on providing appropriate context in order to progress projects and/or develop platforms
• As required train lab personnel in Complex In Vitro Model technology.
• Responsible for developing and managing one or more external CIVM collaborations.

Why you?

Basic Qualifications & Skills:

We are looking for professionals with these required skills to achieve our goals:

• PhD or equivalent life sciences degree in cellular/molecular biology and/or bioengineering with extensive laboratory experience.
• Solid background and experience in cellular and molecular biology.
• Demonstrated experience of a broad range of cell biology and cellular engineering technologies, including minimum of 3 years of experience with organoid culture and / or organ-on-chip technology.
• Experience in the integration of molecular profiling data including transcriptomic, proteomic, and genomic datasets.
• A track record of clear, concise, and effective communication to project teams and preparation and presentation of oral presentations, written reports and posters for internal/external audiences.

Preferred Qualifications & Skills:

Please note the following skills are not necessary, just preferred, if you do not have them, please still apply:

• A post-doc experience in a disease biology or translational models is advantageous.
• Experience in developing complex multicellular models with immune cells.
• Experience working with autoimmune, dermal, epithelial barrier and/or microbiome-competent complex in vitro models.
• Ability to articulate testable hypotheses, process and assess complex data sets, draw conclusions, make data-driven decisions, and develop further insights.
• A track record of identifying experimental or process issues and of effectively implementing solutions for resolution and improvement.
• Biopharmaceutical experience in drug discovery and development.

Closing Date for Applications \xe2\x80\x93 03 Sep 2023 (COB)

Please take a copy of the , as this will not be available post closure of the advert.

When applying for this role, please use the \xe2\x80\x98cover letter\xe2\x80\x99 of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

Why Us?

GSK is a global biopharma company with a special purpose \xe2\x80\x93 to unite science, technology and talent to get ahead of disease together \xe2\x80\x93 so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns \xe2\x80\x93 as an organization where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to positively impact the health of 2.5 billion people by the end of 2030.

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it\xe2\x80\x99s also about making GSK a place where people can thrive. We want GSK to be a workplace where everyone can feel a sense of belonging and thrive as set out in our Equal and Inclusive Treatment of Employees policy. We\xe2\x80\x99re committed to being more proactive at all levels so that our workforce reflects the communities we work and hire in, and our GSK leadership reflects our GSK workforce.

As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on or 0808 234 4391. Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels

As you apply, we will ask you to share some personal information which is entirely voluntary. We want to have an opportunity to consider a diverse pool of qualified candidates and this information will assist us in meeting that objective and in understanding how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it. Rest assured, Hiring Managers do not have access to this information and we will treat your information confidentially.

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GlaxoSmithKline