Job Description

Site Name: UK - Hertfordshire - Stevenage, USA - Massachusetts - Waltham
Posted Date: Nov 28 2023
Senior Scientist \xe2\x80\x93 Exosome Job Purpose We are seeking for a highly motivated scientist with experience in extracellular vesicles (i.e. exosome) isolation and characterization to join the Oncology Translational Research team in GSK. The Oncology Translational Research team will partner with Oncology TA team members increase clinical translatability and to contribute to preclinical development programmes within GSK Oncology TA. The successful candidate will work as part of a team that, by exploiting patient-derived explants/derivatives, is developing and implementing cutting-edge cellular, genomic and molecular techniques with a multimodality analytic approach, plus machine learning models to improve cancer patient risk stratification as well as to predict future targeted and/or immuno-therapy susceptibilities. Key Responsibilities

• Setting up cell protocols for exosomes isolation and characterization from patient-derived explants/derivatives
• Purify exosomes from the cell culture medium using ultracentrifugation or related method, and related process development and optimization
• Developing protocols and conducting experiments for analysis of RNA, DNA length and DNA preparation for sequencing
• Developing protocols and conducting experiments for analysis of proteins isolated from exosomes (dot-blot, flow cytometry assay, proteomics including mass spectrometry, Reverse-phase protein array (RPPA))
• Collecting and reporting data to the Director - Multiomics Patient Derived Explant/ derivatives.
• Interacting with and managing the other (more junior) team members to define the panel of multimodality (DNA/RNA/Protein) markers to be evaluated, in accordance with the mechanisms of action.
• Execute and deliver data of the project to a high quality and within define timeframes
• Solve technical issues operate as part of a cross-functional project team
• Collaborate with Oncology Clinical Development, Project Leadership and Research Unit teams

Closing Date for Applications: 15th December 2023 (COB) Please take a copy of the , as this will not be available post closure of the advert. When applying for this role, please use the \xe2\x80\x98cover letter\xe2\x80\x99 of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application. Basic Qualifications

• BSc or MSc in Cell Biology/Oncology or related , with extensive research experience
• A multidisciplinary mix of training/expertise in cellular biology, oncology as well as integrative data analysis.
• Significant experience in extracellular vesicles and in particular exosomes characterization.
• Cellular Biology skills: extracellular vesicle isolation and characterization; cultures of normal and tumour cells from primary samples or immortalized cell lines.
• Molecular biology skills: nucleic acid extraction; in vitro cell assay (western blot, MTT, cell titre glow, protein quantification); sequencing (gene and/or protein) related to extracellular vesicles.
• Experience with Extracellular Vesicles research
• A strong track record of scientific Publications in the relevant area
• Ability to communicate with team members from different backgrounds by training/discipline, as well as senior members of the GSK stakeholders/research partner units
• Ability to deliver high quality, consistent results in a timely fashion with a positive can-do and result oriented attitude
• Prior experience of managing or supervising (more) junior members in a laboratory

Preferred Qualifications

• Previous pharmaceutical or biotechnology industry research experience working on drug discovery project teams.
• Experience of flow cytometry
• A track record of scientific Publication
• Strong understanding of cancer biology, including the molecular mechanisms underlying tumorigenesis and cancer progression
• Excellent leadership and communication skills
• Strong strategic thinking and problem-solving skills, with the ability to navigate complex scientific and business challenges

Why Us? GSK is a global biopharma company with a special purpose \xe2\x80\x93 to unite science, technology and talent to get ahead of disease together \xe2\x80\x93 so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns \xe2\x80\x93 as an organization where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to positively impact the health of 2.5 billion people by the end of 2030. Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it\xe2\x80\x99s also about making GSK a place where people can thrive. We want GSK to be a workplace where everyone can feel a sense of belonging and thrive as set out in our Equal and Inclusive Treatment of Employees policy. We\xe2\x80\x99re committed to being more proactive at all levels so that our workforce reflects the communities we work and hire in, and our GSK leadership reflects our GSK workforce. As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only). We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are. Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on Ukdiversity.recruitment@gsk.com or 0808 234 4391. Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels As you apply, we will ask you to share some personal information which is entirely voluntary. We want to have an opportunity to consider a diverse pool of qualified candidates and this information will assist us in meeting that objective and in understanding how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it. Rest assured, Hiring Managers do not have access to this information and we will treat your information confidentially. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK\'s commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK\xe2\x80\x99s compliance to all federal and state US Transparency requirements. For more information, please visit GSK\xe2\x80\x99s Transparency Reporting For the Record site.