Job Description

Job Introduction

Materials Characterisation Scientist

Hoddesdon

Pharmaron is a global CRO helping pharma and biotech companies bring new therapies to life. With over 21,000 employees worldwide across 23 sites across the UK, US and China, and we support drug discovery through to manufacturing with fully integrated, high-quality services.


We're proud of the impact we make--just last year, we supported over

780 discovery projects

,

1,000+ CMC programmes

, and

1,000+ clinical trials

across all phases. Our teams are involved in everything from small molecules to gene therapies, and we work with more than

3,000 global customers

.


As a Materials Characterisation Scientist, you'll have the chance to unleash your knowledge in a variety of analytical techniques; providing support in the development and characterisation of Starting Materials, Intermediates, APIs and formulations collaborating effectively with our Process Chemistry, Chemical Engineering, Product Development and Analytical Chemistry colleagues.


You should have a background in Materials Characterisation and Analytical Chemistry combined with expertise in XRPD, DSC, TGA, DVS, microscopy and PSD. Knowledge in the following areas: crystallisation development, process analytical technology, chemical engineering, milling, polymorphism and crystallography, together with knowledge of other analytical methodologies utilised to characterize APIs would be a definite advantage.

At Pharmaron we offer:

Vibrant and dynamic employment -

we are a highly specialised, growth company operating in a critical sector of the economy - our future is strong and exciting!

Opportunities to develop your skills and yourself -

our rapid growth brings greater opportunities for you to learn and grow faster!

A great team where we all support each other -

enjoy your work - after all you spend about a third of your time here!

Key roles and responsibilities

Supporting clients in helping to define final salt and polymorphic form based on a full materials characterisation assessment. Salt and polymorph screening using State of the Art - High Throughput Experimentation. Assessment of polymorph landscape for final APIs and defining thermodynamically stable form. Supporting Process Chemistry to define crystallisation processes by providing materials characterisation assessment of starting materials, intermediates and APIs. Assessment of solubility in a variety of media. Solid State and Solution based Stressed Stability evaluations. Development of crystallisation procedures. Supporting preformulation assessment of final phases. Working within project teams working to tight deadlines. Able to step in and learn new techniques to support projects. Ability to solve scientific problems. Able to work effectively in a GMP laboratory.

Requirements:

MSc in chemistry or relevant related subject with at least 1 year of experience in Materials Characterisation preferably in a Pharmaceutical Development role, or a BSc in chemistry with at least 2 years relevant industrial experience in Materials Characterisation. Significant expertise in troubleshooting and developing materials characterisation methods including XRPD, DSC, TGA, DVS, Microscopy and PSD. In-depth, hands-on expertise and up-to-date knowledge of other analytical methodologies. Knowledge of data analytics and data visualisation tools. Knowledge of crystallisation methodologies relevant to drug substances (Desired). Strong scientific record of accomplishment.

The following skills would also be Desirable:

Modelling and Simulation tools. Computational Software proficiency: Gaussian, Material Studi, ORCA, etc. Force field methods (COMPASS, MMFF94) COSMO-RS Electrostatic potential mapping and analysis Energy minimisation and conformational analysis Hirshfeld surface analysis and lattice energy calculations Coding language Lab automation Amorphous solid dispersions experience

Come and

join a cutting-edge company that tackles the toughest scientific challenges for the world's leading pharmaceutical companies.

Our Company:

"We are a dynamic, fast-growing company, with an enviable reputation for leading edge science, offering contract research services to some of the world's leading pharmaceutical companies, solving what were believed to be unsolvable scientific challenges".


We believe in our ability to relentlessly push forward the boundaries of scientific excellence, delivering solutions for our clients, always operating ethically and with integrity. We take pride in our professionalism and commitment to always deliver our very best work.


We are based in Hertfordshire, in the town of Hoddesdon. The Hoddesdon campus, consisting of several purpose built scientific and administrative buildings together with a purpose-built conference area has more than 5,000 m2 of premier R&D space and houses established Process Chemistry, Analytical Chemistry, Product Development and Drug Discovery teams. The Hoddesdon site has state-of-the-art Good Manufacturing Practice (GMP) standard facilities for the development of Active Pharmaceutical Ingredients (API) and Oral Solid Dose Manufacture, formulation development and process chemistry. We offer our employees a highly supportive team-focused environment, enabling them to develop and fulfil their true potential.


The Analytical Chemistry team at the Hoddesdon site supports other chemistry functions and our science partners with advanced analytical solutions to deliver our clients' programmes and ultimately progress medicines to the market. A career at Pharmaron will give you the opportunity to gain exposure to a wide range of modern analytical techniques (including UHPLC, NMR, and GC-MS) whilst experiencing early- and late-phase pharmaceutical development. You will be able to apply your knowledge and problem-solving skills to a wide variety of R&D projects and to facilitate the development and validation of modern analytical methods for the testing of raw materials, intermediates and APIs and material characterisation. Further opportunities are available in polymorph screening, crystallisation optimisation and pre-formulation development.



We offer a competitive salary and a progressive and comprehensive suite of employee benefits. We offer state of the art working environment on site. We offer the opportunity for growth and development and will support funding for relevant training and development programmes.

Why Should You Apply?

This is an opportunity for you as a Chemistry professional to make a real impact in a highly scientific and regulated environment, demonstrate leadership, ambition and the desire to grow with the department. Build and shape your career in an environment that sets and commits to the highest standards of Chemistry To be part of a team who support each other, embrace and solve technical challenges and put excellence at the heart of all that we do
Pharmaron is a premier R&D service company supporting the life sciences industry. Founded in 2004, Pharmaron has invested in its people and facilities having established diverse drug R&D service capabilities, ranging from synthetic, medicinal, and analytical chemistry, biology, DMPK, pharmacology, drug safety assessment, radiochemistry and isotopically labelled metabolism, chemical & pharmaceutical development to clinical development. With operations in China, US and UK staffed by over 21,000 employees, Pharmaron has an excellent track record in the delivery of R&D solutions to its partners in North America, Europe, Japan, and China.