Job Description

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Description

The purpose of this role is to innovate in the introduction, optimisation and execution of new processes to the CGT Catapult Manufacturing Innovation Centres (MICs). The MS&T (Manufacturing Science and Technology) Scientist will be involved in new product introduction, technology transfer and manufacturing of both Cell Therapy and Viral Gene Therapy processes and aligned modalities within a GMP environment.

The MS&T Scientist will provide technical knowhow in a recognised modality, along with a range of understanding of aligned technologies.###

Key Responsibilities

Use in-depth knowledge of process engineering, aseptic handling, molecular biology, biochemistry and/or purification techniques to evaluate and optimise cell and gene therapy methodologies to support technology transfer of robust and scalable manufacturing processes Support the creation and execution of technology transfer project plans for the introduction of new processes to the CGT Catapult MICs in Stevenage (SMIC) and Braintree (BMIC) Deputise for the MS&T Senior Scientist(s) as required, representing CGT Catapult in technical collaborations Execute hands-on developmental or scale-up runs associated with the establishment of new processes within CGT Catapult Documentation compliance with onsite QMS and HSE Author and review new GMP procedures and batch related documentation for the CGT Catapult MICs Authoring project reports and verbally reporting against project deliverables Strong interaction with Scale Enabling Technology (SET), Quality, and project teams across the CGT Catapult Facilitate collaboration with therapy/technology developers, CMOs and CROs, both at the CGT Catapult MICs and by offsite working

Experience:

A minimum of 1 year's academic or industrial experience in a process development and/or GMP manufacturing setting is essential Demonstratable experience in two or more cell and gene therapy methodologies e.g. mammalian/primary cell culture, single-use stirred tank reactor (STR) operation, chromatography, tangential flow filtration (TFF) and/or normal flow filtration, continuous centrifugation, aseptic handling including tube welding and sealing etc., are essential Experience of working within either the biotech, biopharma, CMO, CRO or other types of commercial-facing organisations is desirable Experience of the Quality by Design (QbD) approach to product development is desirable Experience of working to commercial timelines and within budget is desirable
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Skills, Knowledge and Expertise

Highly motivated, pragmatic, and practical to support the mission of the Cell and Gene Therapy Catapult to accelerate the development of a commercial cell and gene-based therapy industry in the UK Desire to establish a high-profile career within cell and gene sector and the personal drive to help push the sector to be a commercial success Proven knowledge of cutting-edge solutions to address challenges of scalability, and enclosed disposable systems Ability to quickly establish credibility and build rapport and trust Proven ability to engage constructively with colleagues at all levels across different departments to deliver objectives and to respond to a wide range of collaborator and management needs Excellent interpersonal, verbal and written communication skills (including presentation skills) Strong IT and data management/presentation skills Accurate with strong attention to detail A "roll your sleeves up" hands-on attitude towards varying work assignments Resilient, with the ability to manage multiple and varied tasks and prioritise workload within a fast-paced professional environment Flexible and pragmatic, able to learn quickly and respond flexibly to project needs and priorities A good team player with a hands-on approach, and adaptable to new challenges Ambitious, collaborative, driven Ability to work well under pressure, to work independently and to be able to take the initiative when completing tasks A positive attitude towards learning, personal and professional development Keeps up to date with professional knowledge, expertise and best practice Willingness to travel

Education / Qualifications:

Educated to a degree level within a Life Science subject
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About Cell and Gene Therapy Catapult

The Cell and Gene Therapy Catapult (CGT Catapult) is an independent innovation and technology organisation committed to the advancement of cell and gene therapies with a vision of a thriving industry delivering life changing advanced therapies to the world. Its aim is to create powerful collaborations which overcome challenges to the advancement of the sector.

With experts covering all aspects of advanced therapies, it applies its unique capabilities and assets, collaborates with academia, industry and healthcare providers to develop new technology and innovation.

The Cell and Gene Therapy Catapult works with Innovate UK.

CGT Catapult is committed to providing an equal, diverse, and inclusive work environment where everyone's contributions are valued. We celebrate differences, empower, and inspire everyone, because when everyone is included, everyone wins. In 2024, we received bronze accreditation from Inclusive Employers.