Job Description

Applications are invited for a highly motivated and skilled Postdoctoral Research Associate (PDRA) to lead a cutting-edge research project focused on targeting metabolic pathways in human induced pluripotent stem cell (iPS) derived cells. The project will utilize CRISPR-Cas9 technology and other gene editing tool to achieve precise and targeted modifications of iPS-derived cells, specifically microglia and neurons. The primary aim will be the validation of new experimental targets to modulate neuro-immune interactions and halt chronic neuroinflammation. This project is part of a bigger effort aimed at modulating metabolic pathways in microglia to stop secondary neuronal damage and prevent cognitive decline (sponsor: MRC).

The ideal candidate should have:

- PhD in Cell Biology, Molecular Biology, or a related field. - Strong background in CRISPR-Cas9 technology, gene editing, and lentiviral vectors production. - Expertise in cell culture techniques, including experience with human iPS cells (ideally iPS-derived microglia and neurons). - Excellent data analysis and interpretation skills. - Strong written and oral communication skills. - Ability to work independently and as part of a team.

Additional Desirable Skills:

- Understanding of cell metabolism and metabolic pathways. - Knowledge of bioinformatics and computational biology. - Experience with single-cell omics technologies. - Familiarity with databases and software for bioinformatics analyses.


The PDRA will be primarily involved in the design and execution of in vitro experiments and will be responsible for the analysis and interpretation of the obtained data (supervised by Dr. Luca Peruzzotti-Jametti, PI). The role holder may be required to assume further responsibilities in line with the role of a PDRA, in particular the supervision of students and projects within his/her area of expertise.


Cutting-Edge Research in Cell Metabolism: Contribute to our lab's groundbreaking research on cell metabolism and its impact on human health and disease, within the exciting fields of neuroscience and immunology. Thriving Multidisciplinary Environment: Immerse yourself in a vibrant research community within the Clifford Allbutt Building on the Cambridge Biosciences Campus. Benefit from close interactions with:

Department of Clinical Neurosciences:

Collaborate with leading neurologists and pre-clinical researchers, gaining access to cutting-edge clinical research and translating findings into patient care.

Cambridge Clinical School:

Engage in a rich environment with opportunities to participate in educational activities and interact with students and faculty.

Cambridge Center for Myelin Repair (CCMR)

: Work alongside researchers dedicated to regenerative neurology, exploring collaborative projects focused on immunology and remyelination.

UK Dementia Research Institute (UK DRI)

: Connect with researchers at the forefront of dementia research, exploring the complexities of neurodegenerative diseases and contributing to the development of new treatments and preventative strategies. Dynamic Team with Translational Focus: Be an integral part of a dynamic team conducting basic research with the potential to make a real-world impact. Exceptional Collaborations and Growth: Interact with researchers at various career stages, fostering a diverse and enriching learning environment. Engage in collaborative research with groups across the UK, Europe, and the globe. Lead projects and contribute to impactful scientific publications. Supportive Mentorship and Guidance: Receive active supervision and guidance, including regular one-to-one meetings to support your professional development. Comprehensive Support for International Researchers: We are committed to fostering a diverse and inclusive environment. Visa payment is available for international researchers employed on a Skilled Worker or Global Talent Visa where appropriate.



Resources: https://www.LPJlab.org/


Fixed-term: The funds for this post are available for 36 months in the first instance.

Relevant Publications:

Mitochondrial complex I activity in microglia sustains neuroinflammation. Nature. 2024 Apr;628(8006):195-203. doi: 10.1038/s41586-024-07167-9. Metabolic Control of Microglia. Adv Neurobiol. 2024;37:607-622. doi: 10.1007/978-3-031-55529-9_34. Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis. Cell Stem Cell. 2024 Nov 7;31(11):1574-1590.e11. doi: 10.1016/j.stem.2024.09.014. Metabolic Control of Smoldering Neuroinflammation. Front Immunol. 2021 Jun 23;12:705920. doi: 10.3389/fimmu.2021.705920. Targeting Mitochondrial Metabolism in Neuroinflammation: Towards a Therapy for Progressive Multiple Sclerosis. Trends Mol Med. 2018 Oct;24(10):838-855. doi: 10.1016/j.molmed.2018.07.007.

Applicants must have (or be close to obtaining) a PhD.

Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will initially be appointed as a Research Assistant (Grade 5, Point 38 34,610) moving to Research Associate (Grade 7) upon confirmation of your PhD award.


Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.


Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.


Please quote reference RR48525 on your application and in any correspondence about this vacancy.


The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.


The University has a responsibility to ensure that all employees are eligible to live and work in the UK.



Key information

Department/location

Department of Clinical Neurosciences

Salary

37,694-46,049

Reference

RR48525

Category

Research

Date published

15 January 2026

Closing date

9 February 2026