Job Description

Location

Brighton, UK

Hours

Full-time considered up to a maximum of 1.0 FTE (37.5 hours) Requests for flexible working options will be considered (subject to business need).

Salary

Grade 7 starting at 38,249 to 45,413 per annum, pro rata if part time.

Contract Type

Fixed Term Contract
About the role



Tyrosine fusion kinases resulting from chromosomal translocations, are found in haematological malignancies and solid tumours, driving uncontrolled growth of cancer cells. They subsequently serve as biomarkers and therapeutic targets for these cancers. You will join an MRC-funded project, to further understand mechanisms underlying the activation of cancer signalling pathways by tyrosine fusion kinases in Leukaemia, and their regulation by the HSP90 molecular chaperone system. You will test novel approaches to disrupt fusion kinase function, with the aim of identifying new therapeutic targets.



Based in the School of Life Sciences, the Genome Damage and Stability Centre, a university Centre of Excellence, is an internationally renowned Institute carrying out research on the response of cells to DNA damage, genome instability and its relationship to disease. We provide a stimulating and supportive environment with a vibrant network of cancer researchers. Our expertise covers a range of experimental systems with access to state-of-the art facilities. There will also be opportunities to undertake technical and career development skills training.



About you



This project is suitable for a candidate who has completed, or is near to completing a PhD in biochemistry, molecular biology, cell biology or related areas and has experience of working in the cancer signalling or molecular chaperone fields. You will have expertise in mammalian cell culture (cell lines and primary cells) and cell-based assays. Additional experience of large-scale protein production for biochemical and structural studies would be advantageous.


You will have a strong track record of high-quality, peer-reviewed research and will demonstrate excellent written and oral communication skills. You will work independently and collaboratively as part of a multidisciplinary research team and wider network of academic and clinical collaborators, actively participating in scientific discussions, conferences and publications. The successful candidate will bring the enthusiasm, initiative, and organisational skills needed to drive the project forward, while contributing to a supportive, inclusive research environment.



About our School



In the School of Life Sciences we strive to understand the mechanisms that drive biological and chemical processes and to develop innovative and diverse approaches to enhance human health, technology and the environment. We undertake multidisciplinary research, teaching and engagement across a wide range of subjects, from Chemistry through Cellular and Molecular Biosciences to Conservation Biology.


The School comprises five Departments: Biochemistry & Biomedicine, Genome Damage and Stability Centre, Neuroscience, Ecology & Evolution and Chemistry. We also house the Sussex Drug Discovery Centre which works to deliver the bench-to-bedside translation of our discoveries. The breadth and depth of our cutting-edge research and innovative teaching practice is delivered by a diverse community who work across boundaries to deliver excellence, engage with real world problems and produce impact.


We pride ourselves on our world-leading research and have a strong research economy, with approximately 50% of our income stemming from research and an active grant portfolio of over 50 million. We host or form part of three University Centres of Excellence: the Genome Damage and Stability Centre, Sussex Neuroscience and Sussex Sustainability Research Programme. In the 2021 Research Excellence Framework, 90.6 % of our Biological Sciences outputs and 84.8% of our Chemistry outputs were rated as world-leading or internationally excellent. We are proud that in both areas, 100% of our Impact cases were rated as world-leading or internationally excellent.


The School is committed to the University's core values of kindness, integrity, inclusion, collaboration and courage. We believe that equality, diversity and inclusion is everyone's responsibility and aim to provide a friendly and supportive environment for all who work, study and visit the School of Life Sciences.



The School of Life Sciences is proud to hold a Silver Athena Swan Award.



Why work here



Our university is situated off the A27, next to the beautiful South Downs where you will enjoy everything that our 150-acre campus has to offer. We are accessible by public transport; Falmer train station is a five-minute walk to campus and several bus stops are located within campus. We also have dedicated cycling paths and encourage our staff to use these with our offering of a cycle to work scheme.


Sussex is a renowned, multi-accredited, research-led International University and this is only possible because of the people that work here. Whether you are a member of Faculty, part of a Professional Services team or a Student, it's our people that make us great and we want you to be part of that.



Find out about our equality, diversity and inclusion



Further Key Information



Please contact Dr Jasmeen Oberoi (j.oberoi@susssex.ac.uk) for informal enquiries.


Please include a full CV and links to publications and preprints.


The University is committed to equality and valuing diversity, and applications are particularly welcomed from women and black and minority ethnic candidates, who are under-represented in academic posts in Science, Technology, Engineering, Medicine and Mathematics (STEMM) at Sussex.



The University requires that work undertaken for the University is performed in the UK.


Visa Sponsorship Queries: This role has been assigned an eligible SOC code, and meets the salary requirements for Skilled Worker Sponsorship if full time. Please consult our Skilled Worker Visa information page for further information about Visa Sponsorship.




August 14, 2025 5:59 PM

Expected Interview Date

To Be Confirmed

Expected Start Date

01 October 2025

Fixed Term Contract Duration

Fixed Term for 3 years.