Job Description

Location: Science Park - Cambridge, UK

Salary: Competitive with excellent Employee Benefits!

Are you a passionate and curious analytical scientist seeking a role where your expertise can make an extraordinary impact. Join a place built on innovation and creativity, where different views and perspectives are welcomed and valued. An environment that champions inclusion, and teams that reflect the diversity of the communities that we serve.

Working as part of the Compound Synthesis & Management (CS&M) department \xe2\x80\x93 a delivery focused team where we collaborate to support projects aiming to impact patients\xe2\x80\x99 lives. We are responsible for AstraZeneca\xe2\x80\x99s compound collection and it\xe2\x80\x99s application to drug discovery projects. We belong in Discovery Sciences \xe2\x80\x93 our wider function that applies deep technical expertise in specialist technologies to support the delivery of targets and molecules to the early AstraZeneca pipeline.

We are transitioning our group to our exciting new site, The Discovery Centre (DISC) in Cambridge Biomedical Campus and you will get an outstanding opportunity to support the move to our new facilities.

The Discovery Centre (DISC), located at the heart of the Cambridge Biomedical Campus, is designed to play a central role in our mission to deliver life-changing medicines to patients. As our largest research and development centre in the UK, it will have more than 2,000 people working across therapy areas and drug discovery and development once fully occupied.

Find out more about our Cambridge campus and the DISC, here:

What you\xe2\x80\x99ll do

In this varied and exciting position you will be supporting drug discovery by conducting LC-MS analyses for the purity assessment of novel small molecules newly registered into the AZ compound collection. You will also use LC-MS platforms to triage assay hits generated via high throughput screening assays for both AstraZeneca and external partners.

In addition, we will support you to seek out and conduct your own projects that interest you, using LC-MS in conjunction with other analytical techniques as appropriate. Current examples include instrument development and workflow automation, optimising sample integrity and dispense strategies, and supplying data to develop predictive models to facilitate more sustainable operations.

Why Should You Apply?

You relish the opportunity as an LC-MS technical expert to demonstrate your versatility with the platform whilst making a real impact across drug discovery

You enjoy working in a team who support each other, embrace and tackle technical challenges and put excellence at the heart of all that we do

You want to develop your career with our support and achieve scientific visibility through project contributions, presentations and publications

Essential for the role

A good LC-MS background with strong MS interpretation skills are fundamental for the role, with attention to detail essential to provide the best datasets for projects and partners.
A proactive attitude with a delivery focus will be needed to enable timely decision-making for stakeholders across drug discovery functions.
We work collaboratively to tight delivery schedules, so working at a fast, goal-orientated pace, with a team-focused approach is crucial.

We also believe you have:

A BSc/MSc or related qualification in biochemistry/chemistry

A background in UHPLC-MS instrument operation, underpinned by a good understanding of relevant operational software e.g. Waters MassLynx\xe2\x84\xa2

Strong mass spectrometric interpretation skills and an understanding of fragmentation pathways

Excellent problem-solving skills and the ability to identify and implement improvement activities

A real passion for science, technology and innovation with a strong research focus

Desirable

An interest in new technologies and approaches, with a willingness to innovate and help define the future direction of analytical support for drug discovery

A knowledge of Compound Management operation and drug discovery assays

A working knowledge of Waters OpenLynx\xe2\x84\xa2 Open Access Application Manager

Why AstraZeneca

There are many opportunities to develop yourself and your career. From our diverse portfolio and teamwork to our ground breaking innovations \xe2\x80\x93 it\xe2\x80\x99s a place for lifelong learning. Ultimately, it\xe2\x80\x99s more than a job. We know that our work impacts people with serious conditions, many of whom have no other alternatives. That\xe2\x80\x99s what drives us \xe2\x80\x93 the potential to impact over one billion patients worldwide.

So, what\xe2\x80\x99s next

Please complete your application before the below closing date.

This role is open from Wednesday, 19th July 2023 and we welcome your application no later than Monday, 9th August 2023.

Where can I find out more

Follow AstraZeneca on LinkedIn

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We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Date Posted 19-Jul-2023

Closing Date 08-Aug-2023

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

AstraZeneca