Job Description

Senior Scientist - Subject Matter Expert (SME) in Mass Spectrometry

Up to 45,000 + Benefits

Full-time, On-site - Southampton


We're partnering with an innovative scientific organisation to find an experienced

Senior Scientist

with deep expertise in

Mass Spectrometry

to join a high-performing team based in Southampton. This role offers the chance to lead analytical strategies, contribute to cutting-edge projects, and support the development of high-quality modified nucleic acid in a fast-paced, collaborative environment.


About the Role


As the subject matter expert in mass spectrometry, you'll play a central role in driving analytical method development, ensuring high standards in nucleic acid production, and mentoring junior team members. This is a hands-on role in a modern laboratory, where scientific excellence and operational efficiency go hand-in-hand.


Key Responsibilities

Lead and manage analytical workflows using LC-MS, UPLC-MS, HPLC, PAGE, and flash chromatography Act as the go-to expert for mass spectrometry, including troubleshooting and continuous improvement Collaborate with cross-functional teams to support small molecule preparation and oligonucleotide synthesis Maintain, calibrate, and optimise analytical instrumentation in line with internal and ISO quality standards Support and mentor Associate Scientists and Lab Technicians, providing technical guidance and training Ensure high levels of documentation accuracy and data integrity Uphold Health, Safety and Environmental (HSE) standards and promote a safety-first culture Manage the inventory of analytical reagents and consumables Stay informed on emerging techniques in nucleic acid chemistry and analytical science

About You


We're looking for a driven and detail-focused scientist who thrives in a collaborative lab environment and is passionate about pushing the boundaries of analytical science.

You'll ideally have:

PhD in Chemistry, Analytical Chemistry, or a closely related field Significant hands-on experience with Mass Spectrometry, ideally including Waters LC-MS systems (Waters Connect experience highly desirable) Proven track record in high-throughput chemistry or oligonucleotide production environments Strong grounding in nucleic acid chemistry and experience with purification techniques Experience working in ISO or GMP-regulated environments Ability to lead projects and mentor junior staff Excellent communication, problem-solving and organisational skills A proactive mindset, able to adapt and perform under pressure

Salary & Benefits

Salary:

Up to 45,000 depending on experience

Location:

On-site in Southampton

Holidays:

25 days annual leave + 8 bank holidays

Pension:

6% employer contribution

Work-Life Balance:

Flexible working hours

Life Assurance:

4x salary

Other Benefits:

Long service awards Reward and recognition scheme Employee Assistance Programme with 24/7 remote GP access Annual flu vaccinations Cycle to work scheme Gym discounts Discount and savings platform Professional membership reimbursement Referral incentives Social events and volunteering days

Want to lead innovation in mass spectrometry and oligonucleotide production?

If you're ready to make an impact in a dynamic and supportive environment, we'd love to hear from you. Apply today or get in touch to learn more.