Job Description

We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme.
We embrace modern work practises; our Performance with Choice programme offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work.
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At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people's lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients' needs and have the highest probability of success. We're uniting science, technology, and talent to get ahead of disease together.
Principal/ Senior Principal Scientist, Translational Science
Are you driven by the opportunity to bridge preclinical and early clinical proof of concept studies? As a Principal Scientist / Senior Principal Scientist in Translational Science, you will work closely with translational leads to support biomarker identification and assay development activities. This role is highly collaborative, working across multidisciplinary teams to deliver impactful scientific insights.
In this role you will...

• Support identification and validation of clinical biomarkers and development of clinically deployable biomarker assays, including ELISA-based and flow cytometry-based readouts.
• Utilise your expertise in immunology to assist in the design, optimisation, and conduct of in vitro and ex vivo translational assays using primary human cells and tissues.
• Apply expertise in multiple capabilities such as flow cytometry, ELISA/MSD/Luminex, gene/protein expression analysis, cell and tissue imaging, proteomics, and other omics platforms.
• Troubleshoot assays effectively and develop alternative approaches when necessary, working closely with preclinical statistics and other relevant teams to ensure robust study design.
• Present findings to internal teams, stakeholders, and governance in a clear and precise manner while maintaining accurate and detailed laboratory records to ensure compliance with data integrity expectations and safety guidelines.
• Foster a culture of innovation, collaboration, and continuous learning within the translational research team and ensure compliance with all applicable laws, regulations, and ethical standards.

Why you?
Basic Qualifications & Skills:
We are looking for professionals with these required skills to achieve our goals:

• PhD (or equivalent experience) in Cell Biology, Molecular Biology, Immunology or related field with extensive relevant laboratory experience.
• Expertise in primary cell culture as well as at least one of the following techniques: multi-colour flow cytometry, gene expression analysis, immunoassays (ELISA, MSD or Luminex).
• Ability to understand, interpret, and communicate complex scientific data
• Strong written and verbal communication skills, with the ability to effectively present scientific findings to internal and external stakeholders in a balanced, clear, and precise manner.
• Proven ability to balance priorities across multiple objectives, meeting timelines while maintaining attention to detail and high-performance standards.
• Excellent record keeping and organisational skills.

Preferred Qualifications & Skills:
Please note the following skills are not necessary, just preferred, if you do not have them, please still apply:

• Expertise in the development of ELISA-based and flow cytometry-based biomarker assays.
• Background and expertise in autoimmune and immune-mediated diseases.
• Previous experience in pharma or biotech industry; understanding of drug discovery processes including small and large molecule development.
• Experience processing human biological samples, developing B cell, T cell and myeloid cell functional readouts, flexibility to adopt new technologies.

• Knowledge of regulatory guidelines and compliance requirements related to translational research and clinical development.

Closing Date for Applications - October 6th 2025
Please take a copy of the , as this will not be available post closure of the advert.
When applying for this role, please use the 'cover letter' of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.
At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people's lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients' needs and have the highest probability of success. We're uniting science, technology, and talent to get ahead of disease together.
Find out more:
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#LI-GSK
Why GSK?
Uniting science, technology and talent to get ahead of disease together.
GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases - to impact health at scale.
People and patients around the world count on the medicines and vaccines we make, so we're committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.
GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.
We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.
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Skills Required