Job Description

About us...
The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.
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About the role...
The Genetic Mechanisms of Disease lab is a dynamic, supportive and highly collaborative research group which studies how common genetic variation influences the human immune system and how this can predispose to autoimmune and inflammatory disease. A strong background in human immune cell isolation and culture, CRISPR editing and in vitro assays of immune function are essential.
The current project, which is funded via the MSD/Crick Research Alliance, aims to elucidate the biology responsible for a genetic association with inflammatory bowel disease (IBD) which is located on chromosome 5. The associated locus lies within an uncharacterised long non-coding (lnc)RNA and exhibits strong activation-dependent enhancer activity in inflammatory macrophages. The aims of the project are to identify the gene(s) that may be regulated by this dynamic enhancer, investigate whether the lncRNA has RNA-dependent functions and characterise the molecular and cellular mechanisms by which this genetic variation contributes to IBD. Our goal is to not only resolve molecular and cellular mechanisms of disease, but to identify new opportunities for therapy.
For an example of the sort of research we conduct, please see Stankey, Bourges, Haag et al.
What you will be doing...
As a Postdoctoral Fellow at the Crick, you will be:

• Lead your own research projects
• Contribute to other research projects both internally and with external collaborators
• Guide PhD students in their research

About you...
The essential criteria you will bring...

• PhD, or in the final stages of PhD completion, in a relevant biomedical science (including but not limited to: immunology, molecular biology, cell biology, biochemistry)
• Experience in molecular biology, mammalian cell culture and flow cytometry
• Knowledge of human genetics, immunology and gene regulation.
• Experience of working independently, designing experiments and adopting new techniques
• Track record of scientific writing, evidenced by first author publications or submitted manuscripts in refereed journals
• Ability to work independently and as part of a team

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About Working at the Crick...
Our values

• We are bold. We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently.
• We are open. We're highly collaborative and interactive, and make sure our activities are visible to the outside world.
• We are collegial. We show respect for one another, work cooperatively and support the wider community.

At the Crick we believe that diversity and inclusion are essential to driving innovation and scientific discovery.
We are a Disability Confident employer. Please contact for assistance.
Read more about our EDI approach
What will you receive?
We value our team members and offer an extensive range of benefits to support their well-being and development. Find out more .
To apply, please click on the 'Apply' button above.
From 45,500 per annum