Job Description

Grade UE07: 41,064 to 48,822 per annum

CMVM / Human Genetics Unit

Full-time: 35 hours per week

Fixed-term: 2 years

The Opportunity

Transcription-enhanced genome damage in human disease

Transcribed genes are thought to be privileged genomic regions protected from DNA damage and mutation by transcription-coupled repair processes. However, our recent work has demonstrated that transcription in human cells can enhance DNA damage, leading to at least one mutational signature in cancer (Reijns et al , Nature 2022), and has also been detected in ageing brains.



This project will address how and why transcription-associated genome instability occurs in mammalian cells, its initiation and the processes shaping it. Using cellular and mouse model systems, the goal is to establish the role of transcription-induced damage in cancer, and other human diseases. It may also shed light on how DNA damage drives innate immune-mediated inflammation in Aicardi-Goutieres syndrome.



The post-holder will be part of a multidisciplinary team in the lab of Prof. Andrew Jackson, working in a cross-disciplinary environment that addresses both fundamental cellular processes and disease mechanisms. The research group is internationally diverse and strongly competitive consistently publishing in high-level journals including 5 papers published in Science and Nature in the last 10 years. The lab is embedded in the Institute of Genetics and Cancer, a highly collaborative and supportive environment.



For further details on the research group:


https://institute-genetics-cancer.ed.ac.uk/research/research-groups-a-z/a-jackson-group



This post is full-time (35 hours per week) and is fixed term for 2 years.



The salary for this post is

41,064 to 48,822

per annum.



Click to view a copy of the full

job description

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Application Information

Please ensure you include the following documents in your application:


CV Cover letter

As a valued member of our team you can expect:

A competitive salary An exciting, positive, creative, challenging and rewarding place to work To be part of a diverse and vibrant international community Comprehensive Staff Benefits, such as a generous holiday entitlement, competitive pension schemes, staff discounts, and family-friendly initiatives. Check out the full list on our

staff benefits page

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Championing equality, diversity and inclusion

The University of Edinburgh holds a Silver Athena SWAN award in recognition of our commitment to advance gender equality in higher education. We are members of the Race Equality Charter and we are also Stonewall Scotland Diversity Champions, actively promoting LGBT equality.



Prior to any employment commencing with the University you will be required to evidence your right to work in the UK. Further information is available on our

right to work webpages

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The University may be able to sponsor the employment of international workers in this role. This will depend on a number of factors specific to the successful applicant.

Key dates to note

The closing date for applications is

31st October 2025.

Unless stated otherwise the closing time for applications is 11:59pm GMT. If you are applying outside the UK the closing time on our adverts automatically adjusts to your browsers local time zone.







Interviews will be held in November.