Job Description

Dr Rebecca Lee's laboratory, within the Division of Cancer Sciences wish to appoint a laboratory-based Research Technician to an exciting project exploring Immunology and Cancer.


Immune therapy has revolutionised the treatment of many cancers however many challenges remain, with patients still dying from their disease and its complications. Cancer is a highly complex disease and its interaction with immune, parenchymal and stromal cells often leads to therapy resistance. Through greater understanding of these complex relationships, we hope to improve treatments for patients with cancer.


Our major focus is melanoma, which is a type of skin cancer, however many of the processes we observe may have pan-cancer relevance. We are particularly interested in liver metastases and the role they have in generating both local and systemic immune tolerance. Thus, many of our questions are aimed at better understanding of how cancer interacts with liver resident cells, but also more globally how this effects the macroenvironment when liver metastases are present.


We use a variety of state-of-the-art techniques including flow cytometry, spectral flow cytometry, CyTOF, multiplex immunohistochemistry with spatial analysis, single cell RNA sequencing, complex co-culture systems and in vivo models to address our questions.


We closely work with clinicians at The Christie Hospital in Manchester as well as groups both in the UK and internationally to access patient samples and data which feed into our work. Furthermore, we lead on national investigator designed clinical trials addressing important clinical questions, which then feed into our pre-clinical questions.


Our laboratory believes in diversity of thinking, creativity and providing a supportive, kind, joyful environment in which people can flourish.

During this position, the post-holder will undertake a range of activities including:

Conduct pilot programmes of research and to significantly contribute to main research projects by organising, maintaining and reporting on research outcomes, as directed by the Principal Investigator Contribute to the analysis and presentation of data using appropriate systems and methods for inclusion within publications and presentations Use own initiative to find solutions to problems and implementing appropriate changes to working practices. Line Manage Technical Staff within the group, providing support for their training, development and performance. Supervise and advise staff and students on experimental protocols, equipment use, induction and safe working practices Manage the efficient and safe operation of the Group's Laboratory areas. Monitoring both that the activity and personnel are appropriate for the area Ensure systems are in place for monitoring general

What you will get in return:

Fantastic market leading Pension scheme Excellent employee health and wellbeing services including an Employee Assistance Programme Exceptional starting annual leave entitlement, plus bank holidays Additional paid closure over the Christmas period Local and national discounts at a range of major retailers

As an equal opportunities employer we support an inclusive working environment and welcome applicants from all sections of the community regardless of age, disability, ethnicity, gender, gender expression, religion or belief, sex, sexual orientation and transgender status. All appointments are made on merit.


Our University is positive about flexible working you can find out more here

Please note that we are unable to respond to enquiries, accept CVs or applications from Recruitment Agencies.

Any CV's submitted by a recruitment agency will be considered a gift.

Enquiries about the vacancy, shortlisting and interviews:

Name: Dr Rebecca Lee


Email: rebecca.lee-3@manchester.ac.uk

General enquiries:

Email: People.recruitment@manchester.ac.uk

Technical support:

https://jobseekersupport.jobtrain.co.uk/support/home

This vacancy will close for applications at midnight on the closing date.

Please see the link below for the Further Particulars document which contains the person specification criteria.

Please be aware that due to the number of applications we are unfortunately not able to provide individual feedback on your application.