Job Description

The Antibody Discovery & Engineering group is a unit within the newly established Orion Biologics R&D UK Centre whose main responsibility is to discover and develop biologics for clinical use from early research into clinical development and launch.


Orion Pharma is establishing a new Biologics Research & Development Centre in the vibrant biomedical ecosystem of Cambridge, UK. The Biologics R&D Centre represents a central piece in the long-term vision of expansion into biologics modalities by Orion Pharma. The Centre's mission is to accelerate the company's biologics research and development efforts.


The Biologics R&D Centre will complement Orion's existing R&D efforts in Finland, where the company was founded in 1917. Currently, Orion possesses all of the functional capabilities necessary for small molecule discovery and development in Finland. Orion's expansion into Cambridge, UK marks a pivotal step in building future innovative biologics treatments, including multi-specific antibodies, Antibody Drug Conjugates (ADC), and Chimeric Antigen Receptor T cells (CAR-T).


Independently of geography, Orion Pharma is committed to upholding key Nordic values. The company has created a culture of straightforward and honest interactions, and its management emphasizes the balance of professional and home life, leading to happier and motivated employees. This motivation is key to meeting the company's bold mission of becoming a powerhouse of biologics discovery and development.

Your responsibilities include the following:

Development of AI/ML models

to aid antibody candidate selection, support discovery and optimisation via engineering, extract design principles and identify trends in antibody behaviour.

Analyse and interrogate antibody repertoires

using a variety of tools and techniques.

Support and optimise

the integration of data generated by the various functional groups of the Biologics R/D Centre, along with external data sources, and assessment of antibody sequences.

Contribute to the development

of the next generation platform.

Establish in silico screening pipelines

for antibody libraries using AI/ML models and structure-aware filters to prioritise lead candidates.

Evaluate and deploy generative design approaches

for antibody sequence optimisation.

Collaborate cross-functionally

with protein sciences, and discovery biology teams to integrate in silico and experimental design.
The Antibody AI/ML and Bioinformatics Scientist will report to the Director of the Antibody Discovery and Engineering Department, Orion Pharma iMeds/R&D.

What we offer

This opportunity is to create AI/ML and Bioinformatics capabilities within the Antibody Discovery and Engineering Department at our new location in Cambridge, UK; this will be a unique opportunity for an enthusiastic AI/ML antibody scientist to take a leadership role and help establish and further advance a novel technology while we build a state-of-the-art antibody discovery powerhouse within Orion Pharma iMeds/R&D.


A highly innovative R&D pipeline and enthusiastic working environment with possibilities to use your own strengths to advance your competence and career.


The exciting potential to innovate and have an impact on future therapies for patients.


An excellent working atmosphere based on the appreciation of colleagues, continuous development, and mutual trust. Learn more about Orion as an employer https://www.orion.fi/en/careers/orion-as-an-employer/.

Our expectations

:


Ph.D. or MSc. in molecular biology, biochemistry, immunology or a related subject with experience in Bioinformatics and Computational Biology applied to antibody R&D and 5+ years of relevant industrial experience.


A passion for the application of machine learning/deep learning to advance antibody discovery and engineering. Strong scripting and automation skills. Expertise working with antibody sequence and structure datasets. Experience in using antibody in silico tools for predicting antibody properties and guiding engineering campaigns. Familiarity with structural modelling tools and structural antibody engineering is preferred. Experience with bispecifics, multispecifics, Fc engineered, or other antibody-based modalities is a plus. An ability to create productive collaborations within the Research & Development team Demonstrated ability to meet performance targets and project initiatives Ability to work independently and collaboratively in multidisciplinary environments. Excellent oral and written communication, interpersonal, and analytical skills

How to apply and additional information

Please submit your CV and Cover letter by 19 September 2025.


We typically review applications already during the application period and may start interviewing candidates before the application deadline. Therefore, we invite you to send your application as soon as possible.


#LI-ORION

Unit description

Orion's pharmaceutical innovations are created within its R&D organization. We employ around 400 top professionals in the field of drug discovery and development. We work globally: in Espoo and Turku in Finland, in Nottingham in England and in New York, NY, USA. Orion R&D and the Innovative Medicines business division are dedicated to making a transformation to become a global player in the pain and oncology therapy areas.